Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medullo...
Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity
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Publisher
Cold Spring Harbor Laboratory
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Language
English
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Publisher
Cold Spring Harbor Laboratory
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Contents
We report a novel, nanoparticle formulation of the SHH pathway inhibitor vismodegib that improves efficacy for medulloblastoma treatment while reducing toxicity. Systemic therapies for brain tumors are complicated by restricted blood-brain barrier (BBB) permeability and dose-limiting extraneural toxicity, therefore improved delivery approached are...
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Full title
Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity
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Record Identifier
TN_cdi_biorxiv_primary_2020_04_30_068726
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2020_04_30_068726
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2020.04.30.068726
