Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell factor for viral entry and pathogenesis of SARS-coronavirus-2 (SARS-CoV-2). Specifically, TMPRSS2 proteolytically processes the SARS-CoV-2 Spike (S) Protein, enabling virus-host membrane fusion and infection of the lungs. We present here an efficient recombinant product...
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Full title
Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
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Record Identifier
TN_cdi_biorxiv_primary_2021_06_23_449282
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2021_06_23_449282
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2021.06.23.449282
