The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimenta...
The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease
About this item
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Author / Creator
Kedariti, Maria , Frattini, Emanuele , Baden, Pascale , Cogo, Susanna , Civiero, Laura , Ziviani, Elena , Aureli, Massimo , Kaganovich, Alice , Cookson, Mark R , Stefanis, Leonidas R , Surface, Matthew , Deleidi, Michela , Alessio Di Fonzo , Alcalay, Roy N , Rideout, Hardy , Greggio, Elisa and Plotegher, Nicoletta
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
LRRK2 is a kinase involved in different cellular functions, including autophagy, endolysosomal pathways and vesicle trafficking. Mutations in LRRK2 cause autosomal dominant forms of Parkinson's disease (PD). Heterozygous mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase (GCase), are the most common genetic risk factors fo...
Alternative Titles
Full title
The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease
Authors, Artists and Contributors
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Record Identifier
TN_cdi_biorxiv_primary_2021_09_27_461935
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2021_09_27_461935
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2021.09.27.461935
