E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
About this item
Full title
Author / Creator
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
Formats
Publication information
Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Subjects
More information
Scope and Contents
Contents
Intrinsic apoptosis is principally governed by the BCL-2 family of proteins, but some non-BCL-2 proteins are also critical to control this process. To identify novel apoptosis regulators, we performed a genome-wide CRISPR-Cas9 library screen, and identified the mitochondrial E3 ubiquitin ligase MARCHF5/MITOL/RNF153 as an important regulator of BAK...
Alternative Titles
Full title
E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_biorxiv_primary_2022_01_04_474880
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2022_01_04_474880
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2022.01.04.474880
