Excess ribosomal protein production unbalances translation in Fragile X Syndrome
Excess ribosomal protein production unbalances translation in Fragile X Syndrome
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Scope and Contents
Contents
Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes arise from the excessive translation of mRNAs downstream of mGlu1/5 activation. Here, we use a combination of CA1 pyramidal neuron-specific TRAP-seq and proteomics to identify the overtranslati...
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Full title
Excess ribosomal protein production unbalances translation in Fragile X Syndrome
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Record Identifier
TN_cdi_biorxiv_primary_2022_04_07_487442
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2022_04_07_487442
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2022.04.07.487442
