Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differe...
Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
DNA methylation maintenance is essential for cell fate inheritance. In differentiated cells, this involves the orchestrated actions of DNMT1 and UHRF1. In mice, high-affinity binding of DPPA3 to the UHRF1 PHD finger regulates UHRF1 chromatin dissociation and cytosolic localization, which is required for oocyte maturation and early embryo developmen...
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Full title
Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3
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TN_cdi_biorxiv_primary_2024_01_11_575164
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2024_01_11_575164
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ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.01.11.575164
