High-resolution lineage tracking of within-host evolution and strain transmission in a human gut sym...
High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Gut bacteria rapidly evolve in vivo, but their long-term success requires dispersal across hosts. Here, we quantify this interplay by tracking >50,000 genomically barcoded lineages of the prevalent commensal Bacteroides thetaiotaomicron (Bt) among co-housed mice. We find that adaptive mutations rapidly spread between hosts, overcoming the natural c...
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Full title
High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales
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Record Identifier
TN_cdi_biorxiv_primary_2024_02_17_580834
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2024_02_17_580834
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.02.17.580834
