A Robust Computational Framework for the Optimization of CDK7 Inhibitors as Promising Cancer Therapy
A Robust Computational Framework for the Optimization of CDK7 Inhibitors as Promising Cancer Therapy
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Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title
Language
English
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Publisher
Cold Spring Harbor: Cold Spring Harbor Laboratory Press
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Contents
Cyclin-dependent kinase 7 (CDK7) plays a crucial role in cell cycle regulation and transcription, establishing it as a promising target for cancer therapy. Although the covalent inhibitor THZ1 effectively targets CDK7, it presents risks such as short half-life and potential off-target side effects. To address these limitations, we employed a comput...
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Full title
A Robust Computational Framework for the Optimization of CDK7 Inhibitors as Promising Cancer Therapy
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TN_cdi_biorxiv_primary_2024_11_13_623385
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2024_11_13_623385
Other Identifiers
ISSN
2692-8205
E-ISSN
2692-8205
DOI
10.1101/2024.11.13.623385
