In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutraliz...
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
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Publisher
Cold Spring Harbor Laboratory
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Language
English
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Publisher
Cold Spring Harbor Laboratory
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Scope and Contents
Contents
Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental validatio...
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Full title
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
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Record Identifier
TN_cdi_biorxiv_primary_2025_06_04_657802
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_biorxiv_primary_2025_06_04_657802
Other Identifiers
E-ISSN
2692-8205
DOI
10.1101/2025.06.04.657802
