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贫铀吸入性肺损伤犬模型的建立

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贫铀吸入性肺损伤犬模型的建立

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_backfile_36522464

贫铀吸入性肺损伤犬模型的建立

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Full title

贫铀吸入性肺损伤犬模型的建立

Author / Creator

张斌 段蕴铀 贺文博 冯华松 宁浩勇 温居一 杨陟华 潘秀颉 曹珍山 朱茂祥 徐勤枝 周平坤 丁新民

Journal title

Jie fang jun yi xue za zhi, 2011, Vol.36 (2), p.188-191

Language

Chinese

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Contents

目的建立适用于亚急性贫铀吸入性肺损伤研究的犬模型。方法将26只犬随机分为对照组（n=6）、低剂量组（n=10）和高剂量组（n=10）。3组犬麻醉后经气管插管,行左侧肺灌注,对照组给予0.2ml/kg生理盐水,低、高剂量组分别给予低浓度（10mg/ml）和高浓度（100mg/ml）贫铀混悬液。记录贫铀灌注后各组犬的生存时间,观察时间截止为贫铀灌注后30d。在灌注后31d,对存活犬行胸部CT检查,处死后取肺组织行病理检查。结果在30d的观察期内,对照组动物无死亡,低剂量组中1只犬在贫铀灌注后22d死亡,其余犬存活均超过30d;高剂量组所有犬均在30d内死亡,存活时间11.2±8.9（中位值12）d。高剂量组与低剂量组和对照组比较,差异有统计学意义（P=0.000）,但后两组比较差异无统计学意义（...

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贫铀吸入性肺损伤犬模型的建立

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TN_cdi_chongqing_backfile_36522464

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_backfile_36522464

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ISSN

0577-7402

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