艾塞那肽对间歇性高糖环境下胰岛INS-1细胞的保护作用
艾塞那肽对间歇性高糖环境下胰岛INS-1细胞的保护作用
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目的评价间歇性高糖对胰岛β细胞的损害及艾塞那肽(Exenatide)的保护作用。方法取大鼠胰岛INS-1细胞分为5组;正常糖(5.5mmol/L)对照组、恒定性高糖(30mmol/L)组和恒定性高糖+Exenatide(100nmol/L)组按分组所述对细胞进行培养,间歇性高糖组和间歇性高糖+Exenatide组采用高糖与正常糖交替(每24h更替1次)培养细胞。培养7d后检测各组细胞内活性氧自由基(ROS)和黄嘌呤氧化酶(XOD)水平,同时检测细胞增殖和凋亡情况。结果与正常糖对照组比较,恒定性高糖组及间歇性高糖组细胞内ROS、XOD水平和细胞凋亡率明显增加(P〈0.01),细胞增殖活性明显降低(P〈0.01),尤以间歇性高糖组更为明显。恒定性高糖+Exenatide组的ROS、XOD水平和细...
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艾塞那肽对间歇性高糖环境下胰岛INS-1细胞的保护作用
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TN_cdi_chongqing_backfile_37666712
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_backfile_37666712
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0577-7402