Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tum...
Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
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English
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Fbw7 and Cdhl are substrate-recognition subunits of the SCF- and APC-type E3 ubiquitin ligases, respectively. There is emerging evidence suggesting that both Fbw7 and Cdhl function as tumor suppressors by targeting onco- proteins for destruction. Loss of Fbw7, but not Cdhl, is frequently observed in various human tumors. However, it remains largely...
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Regulation of APC^cdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
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TN_cdi_chongqing_primary_46553897
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_primary_46553897
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2013.67
