HBsAg和抗HBs双阳性患者S基因新增N-糖基化突变的意义
HBsAg和抗HBs双阳性患者S基因新增N-糖基化突变的意义
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HBsAg和抗HBs双阳性患者S基因新增N-糖基化突变的意义
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Journal title
解放军医学杂志, 2016, Vol.41 (5), p.351-357
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Chinese
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目的分析乙型肝炎病毒（HBV）HBsAg＋抗HBs双阳性患者S基因主要亲水区（MHR）新增N-糖基化突变的特点,探讨HBsAg＋抗HBs双阳性的发生机制和临床意义。方法对284例HBsAg＋抗HBs双阳性和314例HBsAg单阳性的慢性HBV感染者S基因进行测序分析。对1例携有MHR区双N-糖基化新型突变株的慢性乙肝患者样本进行随访收集和研究。构建双N-糖基化突变和对照前S/S基因重组质粒,转染HepG2细胞,分析突变对病毒复制力和抗原性的影响。结果 HBsAg＋抗HBs双阳性患者MHR区新增N-糖基化突变的检出率为11.3%（32/284）,显著高于HBsAg单阳性患者的2.9%（9/314）（P〈0.01）。HBsAg＋抗HBs双阳性组中,72例肝细胞癌（HCC）在N-糖基化突变阳性和阴...
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HBsAg和抗HBs双阳性患者S基因新增N-糖基化突变的意义
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TN_cdi_chongqing_primary_669018779
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_primary_669018779
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0577-7402
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