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观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活

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观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_primary_689907875200603001

观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活

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Full title

观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活

Author / Creator

Xue-Sen Zhang~+ Zhi-Hong Zhang~+ Shu-Hua Guo Wei Yang,Zhu-Qiang Zhang Jin-Xiang Yuan Xuan Jin Zhao-Yuan Hu Yi-Xun Liu State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,25 Bei Si Huan Road West,Beijing 100081,China

Journal title

亚洲男性学杂志：英文版, 2006 (3), p.265-272

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English

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目的:观察恒河猴隐睾(热刺激)模型中睾丸细胞外信号调节激酶1和2(ERK1/2),c-Jun N 末端激酶(JNKs)和 p38有丝分裂原激活蛋白激酶(MAPK)的时空表达变化并探讨其参与支持细胞去分化的可能调节作用。方法:通过免疫组化和 Western blot 方法观察 ERK1/2、p38以及 JNK 在处于隐睾不同时期的睾丸中的表达变化。结果:腹部温度没有明显改变隐睾的睾丸细胞中的 ERK1/2表达量,但明显活化了磷酸化 ERK1/2在支持细胞中的表达。腹腔内的热压明显增加睾丸细胞中 JNK 总体水平的表达,但没有活化磷酸化 JNK 的表达。睾丸细胞内磷酸化 p38以及非磷酸化的 p38的表达不受热刺激的影响。不成熟或未分化的支持细胞的标志分子(CK-18)的时空表达变化与 ERK1...

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观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活

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TN_cdi_chongqing_primary_689907875200603001

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_chongqing_primary_689907875200603001

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ISSN

1008-682X

E-ISSN

1745-7262

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