Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers ag...
Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Type 1 angiotensin II (AT
1
) receptor has a critical role in the development of load-induced cardiac hypertrophy. Recently, we showed that mechanical stretching of cells activates the AT
1
receptor without the involvement of angiotensin II (AngII) and that this AngII-independent activation is inhibited by the inverse agonistic activity...
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Full title
Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation
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TN_cdi_crossref_citationtrail_10_1038_hr_2009_117
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1038_hr_2009_117
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ISSN
0916-9636
E-ISSN
1348-4214
DOI
10.1038/hr.2009.117
