Crystal Structures of 2-Acetylaminofluorene and 2-Aminofluorene in Complex with T7 DNA Polymerase Re...
Crystal Structures of 2-Acetylaminofluorene and 2-Aminofluorene in Complex with T7 DNA Polymerase Reveal Mechanisms of Mutagenesis
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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The carcinogen 2-acetylaminofluorene forms two major DNA adducts: N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) and its deacetylated derivative, N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (dG-AF). Although the dG-AAF and dG-AF adducts are distinguished only by the presence or absence of an acetyl group, they have profoundly different effe...
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Full title
Crystal Structures of 2-Acetylaminofluorene and 2-Aminofluorene in Complex with T7 DNA Polymerase Reveal Mechanisms of Mutagenesis
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TN_cdi_crossref_citationtrail_10_1073_pnas_0406516101
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0406516101
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0406516101
