Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9
Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause an autosomal dominant form of hypercholesterolemia in humans, likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 reduces hepatic LDL receptor protei...
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Full title
Decreased Plasma Cholesterol and Hypersensitivity to Statins in Mice Lacking Pcsk9
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TN_cdi_crossref_citationtrail_10_1073_pnas_0501652102
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0501652102
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0501652102
