Ab-Induced Ectodomain Shedding Mediates Hepatocyte Growth Factor Receptor down-Regulation and Hamper...
Ab-Induced Ectodomain Shedding Mediates Hepatocyte Growth Factor Receptor down-Regulation and Hampers Biological Activity
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN30). In vitro, chronic treatmen...
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Full title
Ab-Induced Ectodomain Shedding Mediates Hepatocyte Growth Factor Receptor down-Regulation and Hampers Biological Activity
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TN_cdi_crossref_citationtrail_10_1073_pnas_0508156103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0508156103
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0508156103
