Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae...
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The Streptococcus pneumoniae toxin pneumolysin belongs to the group of cholesterol-dependent cytolysins. It produces rapid cell lysis at higher concentrations or apoptosis at lower concentrations. In cell membranes, it forms prepores and pores. Here, we show that sublytic concentrations of pneumolysin produce rapid activation of Rho and Rac GTPases...
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Full title
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin
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TN_cdi_crossref_citationtrail_10_1073_pnas_0608213104
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0608213104
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0608213104
