Continuum of Prion Protein Structures Enciphers a Multitude of Prion Isolate-Specified Phenotypes
Continuum of Prion Protein Structures Enciphers a Multitude of Prion Isolate-Specified Phenotypes
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn-HCI) concentration required to denature 50% of disease-causing prion protein ($PrP^{Sc}$) molecules, denoted as the $[Gdn\cdotHCl]_{1/2}$ value. For the two pri...
Alternative Titles
Full title
Continuum of Prion Protein Structures Enciphers a Multitude of Prion Isolate-Specified Phenotypes
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_citationtrail_10_1073_pnas_0608970103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0608970103
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0608970103
