Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants in p53 and MDM2 have shown that single nucleotide...
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Full title
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
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TN_cdi_crossref_citationtrail_10_1073_pnas_0901298106
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0901298106
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0901298106
