Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma
Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma
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National Academy of Sciences
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Language
English
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National Academy of Sciences
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Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1α correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8. Significant up-regulation of antiangiogenic gene tra...
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Full title
Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma
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TN_cdi_crossref_citationtrail_10_1073_pnas_0914072107
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_0914072107
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0914072107
