Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Following its tyrosine phosphorylation, STAT3 is methylated on K140 by the histone methyl transferase SET9 and demethylated by LSD1 when it is bound to a subset of the promoters that it activates. Methylation of K140 is a negative regulatory event, because its blockade greatly increases the steady-state amount of activated STAT3 and the expression...
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Full title
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
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TN_cdi_crossref_citationtrail_10_1073_pnas_1016147107
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1016147107
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1016147107
