Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
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Author / Creator
Westfield, Gerwin H. , Rasmussen, Søren G. F. , Su, Min , Dutta, Somnath , DeVree, Brian T. , Chung, Ka Young , Calinski, Diane , Velez-Ruiz, Gisselle , Oleskie, Austin N. , Pardon, Els , Chae, Pil Seok , Liu, Tong , Li, Sheng , Woods, Virgil L. , Steyaert, Jan , Kobilka, Brian K. , Sunahara, Roger K. and Skiniotis, Georgios
Journal title
Language
English
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Contents
The active-state complex between an agonist-bound receptor and a guanine nucleotide-free G protein represents the fundamental signaling assembly for the majority of hormone and neurotransmitter signaling. We applied single-particle electron microscopy (EM) analysis to examine the architecture of agonist-occupied β
2
-adrenoceptor (β
2
A...
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Full title
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
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TN_cdi_crossref_citationtrail_10_1073_pnas_1113645108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1113645108
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1113645108
