Pictet-Spengler ligation for protein chemical modification
Pictet-Spengler ligation for protein chemical modification
About this item
Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Aldehyde- and ketone-functionalized proteins are appealing substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with α-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively. However, t...
Alternative Titles
Full title
Pictet-Spengler ligation for protein chemical modification
Authors, Artists and Contributors
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Record Identifier
TN_cdi_crossref_citationtrail_10_1073_pnas_1213186110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1213186110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1213186110
