Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix ri...
Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Cells can sense and respond to physical properties of their surrounding extracellular matrix. We have demonstrated here that tyrosine phosphatase Shp2 plays an essential role in the response of mouse embryonic fibroblasts to matrix rigidity. On rigid surfaces, large focal adhesions (FAs) and anisotropically oriented stress fibers are formed, wherea...
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Full title
Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity
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TN_cdi_crossref_citationtrail_10_1073_pnas_1222164110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1222164110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1222164110
