Overlapping hotspots in CDRs are critical sites for V region diversification
Overlapping hotspots in CDRs are critical sites for V region diversification
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Activation-induced deaminase (AID) mediates the somatic hypermutation (SHM) of Ig variable (V) regions that is required for the affinity maturation of the antibody response. An intensive analysis of a published database of somatic hypermutations that arose in theIGHV3-23*01human V region expressed in vivo by human memory B cells revealed that the f...
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Full title
Overlapping hotspots in CDRs are critical sites for V region diversification
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TN_cdi_crossref_citationtrail_10_1073_pnas_1500788112
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1500788112
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1500788112
