Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer intera...
Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF’s hemostatic potential is important to mediate pl...
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Full title
Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction
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Record Identifier
TN_cdi_crossref_citationtrail_10_1073_pnas_1516214113
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1516214113
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1516214113
