Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice
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Author / Creator
Nishio, Miki , Sugimachi, Keishi , Goto, Hiroki , Wang, Jia , Morikawa, Takumi , Miyachi, Yosuke , Takano, Yusuke , Hikasa, Hiroki , Itoh, Tohru , Suzuki, Satoshi O. , Kurihara, Hiroki , Aishima, Shinichi , Leask, Andrew , Sasaki, Takehiko , Nakano, Toru , Nishina, Hiroshi , Nishikawa, Yuji , Sekido, Yoshitaka , Nakao, Kazuwa , Shin-ya, Kazuo , Mimori, Koshi and Suzuki, Akira
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant...
Alternative Titles
Full title
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice
Authors, Artists and Contributors
Author / Creator
Sugimachi, Keishi
Goto, Hiroki
Wang, Jia
Morikawa, Takumi
Miyachi, Yosuke
Takano, Yusuke
Hikasa, Hiroki
Itoh, Tohru
Suzuki, Satoshi O.
Kurihara, Hiroki
Aishima, Shinichi
Leask, Andrew
Sasaki, Takehiko
Nakano, Toru
Nishina, Hiroshi
Nishikawa, Yuji
Sekido, Yoshitaka
Nakao, Kazuwa
Shin-ya, Kazuo
Mimori, Koshi
Suzuki, Akira
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Primary Identifiers
Record Identifier
TN_cdi_crossref_citationtrail_10_1073_pnas_1517188113
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1517188113
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1517188113
