Cancer Regression and Autoimmunity Induced by Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade i...
Cancer Regression and Autoimmunity Induced by Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma
About this item
Full title
Author / Creator
Phan, Giao Q. , Yang, James C. , Sherry, Richard M. , Hwu, Patrick , Topalian, Suzanne L. , Schwartzentruber, Douglas J. , Restifo, Nicholas P. , Haworth, Leah R. , Seipp, Claudia A. , Freezer, Linda J. , Morton, Kathleen E. , Mavroukakis, Sharon A. , Duray, Paul H. , Steinberg, Seth M. , Allison, James P. , Davis, Thomas A. and Rosenberg, Steven A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell activation. Blockade of CTLA-4 has been shown in animal models to improve the effectiveness of cancer immunotherapy. We thus treated 14 patients with metas...
Alternative Titles
Full title
Cancer Regression and Autoimmunity Induced by Cytotoxic T Lymphocyte-Associated Antigen 4 Blockade in Patients with Metastatic Melanoma
Authors, Artists and Contributors
Author / Creator
Yang, James C.
Sherry, Richard M.
Hwu, Patrick
Topalian, Suzanne L.
Schwartzentruber, Douglas J.
Restifo, Nicholas P.
Haworth, Leah R.
Seipp, Claudia A.
Freezer, Linda J.
Morton, Kathleen E.
Mavroukakis, Sharon A.
Duray, Paul H.
Steinberg, Seth M.
Allison, James P.
Davis, Thomas A.
Rosenberg, Steven A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_citationtrail_10_1073_pnas_1533209100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_1533209100
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1533209100
