hMutSα - and hMutLα -Dependent Phosphorylation of p53 in Response to DNA Methylator Damage
hMutSα - and hMutLα -Dependent Phosphorylation of p53 in Response to DNA Methylator Damage
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Publisher
National Academy of Sciences of the United States of America
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Language
English
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National Academy of Sciences of the United States of America
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Contents
$\text{hMSH2}· \text{hMSH6}$ heterodimer (hMutSα) and $\text{hMLH1}· \text{hPMS2}$ complex (hMutLα) have been implicated in the cytotoxic response of mammalian cells to a number of DNA-damaging compounds, including methylating agents that produce O6-methylguanine (O6MeG) adducts. This study demonstrates that O6MeG lesions, in which the damaged base...
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Full title
hMutSα - and hMutLα -Dependent Phosphorylation of p53 in Response to DNA Methylator Damage
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TN_cdi_crossref_citationtrail_10_1073_pnas_96_22_12384
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1073_pnas_96_22_12384
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.22.12384
