Early weight gain after diagnosis may have an impact on remission status in children with new‐onset...
Early weight gain after diagnosis may have an impact on remission status in children with new‐onset type 1 diabetes mellitus
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背景:残余β细胞功能和通过逆转葡萄糖毒性改善胰岛素敏感性被认为是与部分缓解(PR)相关的两种现象。体脂质量是胰岛素敏感性的主要决定因素。本研究旨在调查1型糖尿病(T1DM)诊断后体重增加率与其他临床因素之间的关系，以确定PR的发生和持续时间
方法:将新发T1DM儿童(2‐16岁)(n=99)根据胰岛素剂量调整后的HbA1c值分为缓解组和非缓解组。记录实验室和临床数据以及诊断时和每次随访时每千克体重的每日胰岛素需求量，确定PR持续时间。以每六个月收集的生长发育数据，计算体重指数标准差评分(BMI‐SDS)的变化
结果:47名患者(47.5%)病情缓解，52名患者(52.5%)病情未缓解。诊断后前6个月，病情未缓解患者的BMI‐SDS平均增加值高于病情缓解患者(p=0.04)。PR持...
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Early weight gain after diagnosis may have an impact on remission status in children with new‐onset type 1 diabetes mellitus
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TN_cdi_crossref_citationtrail_10_1111_1753_0407_13455
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1111_1753_0407_13455
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1753-0393
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1753-0407
DOI
10.1111/1753-0407.13455
