Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
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Publisher
American Association for the Advancement of Science
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Language
English
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Publisher
American Association for the Advancement of Science
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Scope and Contents
Contents
Cancers often evade immune surveillance by adopting peripheral tissue–tolerance mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1), the inhibition of which results in potent antitumor immunity. Here, we show that cyclindependent kinase 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic neurons and in...
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Full title
Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
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Record Identifier
TN_cdi_crossref_citationtrail_10_1126_science_aae0477
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_citationtrail_10_1126_science_aae0477
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aae0477
