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Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1002_1878_0261_13728

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

About this item

Full title

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

Journal title

Molecular oncology, 2025-02, Vol.19 (2), p.496-518

Language

English

Formats

More information

Scope and Contents

Contents

In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant‐7 (ARV7) is clinically the most relevant and has a distinct 3′ untranslated region (3′UTR) compared to th...

Alternative Titles

Full title

Targeting the CLK 2/ SRSF 9 splicing axis in prostate cancer leads to decreased ARV 7 expression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1002_1878_0261_13728

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1002_1878_0261_13728

Other Identifiers

ISSN

1574-7891

E-ISSN

1878-0261

DOI

10.1002/1878-0261.13728

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