An in vitro model for assessment of drug-induced torsade de pointes arrhythmia: Effects of haloperid...
An in vitro model for assessment of drug-induced torsade de pointes arrhythmia: Effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Language
English
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Contents
Torsade de pointes (TdP) is a serious side effect of many drugs. We aimed to establish an in vitro TdP model for drug testing, which includes typical risk factors, such as female gender, hypokalemia, low magnesium levels, and bradycardia. Isolated, spontaneously beating rabbit hearts (female White New Zealand rabbits) were perfused according to the...
Alternative Titles
Full title
An in vitro model for assessment of drug-induced torsade de pointes arrhythmia: Effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia
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Record Identifier
TN_cdi_crossref_primary_10_1007_s00210_008_0329_0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1007_s00210_008_0329_0
Other Identifiers
ISSN
0028-1298
E-ISSN
1432-1912
DOI
10.1007/s00210-008-0329-0
