Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downre...
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downregulation are required for shikonin-induced apoptosis
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Boston: Springer US
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Boston: Springer US
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Shikonin derivatives exert powerful cytotoxic effects, induce apoptosis and escape multidrug resistance in cancer. However, the diverse mechanisms underlying their anticancer activities are not completely understood. Here, we demonstrated that shikonin-induced apoptosis is caused by reactive oxygen species (ROS)-mediated activation of Akt/ASK1/p38...
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Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downregulation are required for shikonin-induced apoptosis
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TN_cdi_crossref_primary_10_1007_s10495_013_0835_5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1007_s10495_013_0835_5
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1360-8185
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1573-675X
DOI
10.1007/s10495-013-0835-5
