Synthetische Zipper für die Biosynthese neuer Naturstoffderivate
Synthetische Zipper für die Biosynthese neuer Naturstoffderivate
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German
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A rich source of new therapeutics are natural products derived from modular non-ribosomal peptide synthetases (e. g. penicillins, daptomycin). Yet, efficient bioengineering of these often gigantic megaenzymes to generate natural product analogs is a major challenge. Using synthetic zippers, we have established a co-expression strategy that not only...
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Synthetische Zipper für die Biosynthese neuer Naturstoffderivate
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TN_cdi_crossref_primary_10_1007_s12268_022_1785_7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1007_s12268_022_1785_7
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ISSN
0947-0867
E-ISSN
1868-6249
DOI
10.1007/s12268-022-1785-7