Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
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Author / Creator
Choi, Jang Hyun , Banks, Alexander S. , Kamenecka, Theodore M. , Busby, Scott A. , Chalmers, Michael J. , Kumar, Naresh , Kuruvilla, Dana S. , Shin, Youseung , He, Yuanjun , Bruning, John B. , Marciano, David P. , Cameron, Michael D. , Laznik, Dina , Jurczak, Michael J. , Schürer, Stephan C. , Vidović, Dušica , Shulman, Gerald I. , Spiegelman, Bruce M. and Griffin, Patrick R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Towards better antidiabetic drugs
The nuclear receptor PPARγ is the target of thiazolidinedione antidiabetics including rosiglitazone and pioglitazone. These full PPARγ agonists are effective and well tolerated in most patients, but cause fluid retention and weight gain in a minority. In this proof-of-concept study, Choi
et al
. show the d...
Alternative Titles
Full title
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
Authors, Artists and Contributors
Author / Creator
Banks, Alexander S.
Kamenecka, Theodore M.
Busby, Scott A.
Chalmers, Michael J.
Kumar, Naresh
Kuruvilla, Dana S.
Shin, Youseung
He, Yuanjun
Bruning, John B.
Marciano, David P.
Cameron, Michael D.
Laznik, Dina
Jurczak, Michael J.
Schürer, Stephan C.
Vidović, Dušica
Shulman, Gerald I.
Spiegelman, Bruce M.
Griffin, Patrick R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1038_nature10383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1038_nature10383
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10383
