Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic...
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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α-synuclein is an abundant presynaptic protein that is important for regulation of synaptic vesicle trafficking, and whose misfolding plays a key role in Parkinson’s disease. While α-synuclein is disordered in solution, it folds into a helical conformation when bound to synaptic vesicles. Stabilization of helical, folded α-synuclein might therefore...
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Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
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TN_cdi_crossref_primary_10_1038_ncomms6857
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1038_ncomms6857
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6857
