Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
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Publisher
Boston, MA: Massachusetts Medical Society
Journal title
Language
English
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Publisher
Boston, MA: Massachusetts Medical Society
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Scope and Contents
Contents
The authors describe a patient with life-threatening opioid intoxication despite having received only moderate doses of codeine. Blood levels of morphine and morphine-6-glucuronide were elevated. CYP2D6 genotyping showed three or more functional alleles, a finding consistent with ultrarapid metabolism. Toxicity was attributed to this genotype, in c...
Alternative Titles
Full title
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
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TN_cdi_crossref_primary_10_1056_NEJMoa041888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1056_NEJMoa041888
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa041888
