Molecular bases of defective signal transduction in the platelet P2Y 12 receptor of a patient with c...
Molecular bases of defective signal transduction in the platelet P2Y 12 receptor of a patient with congenital bleeding
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Language
English
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Contents
We have identified structural attributes required for signal transduction through a seven-transmembrane-domain receptor. Platelets from a patient (AC) with a congenital bleeding disorder had normal shape change but reduced and reversible aggregation in response to 4 μM ADP, similar to normal platelets with blocked P2Y
12
receptor. The respons...
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Full title
Molecular bases of defective signal transduction in the platelet P2Y 12 receptor of a patient with congenital bleeding
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TN_cdi_crossref_primary_10_1073_pnas_0437879100
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0437879100
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0437879100
