Small-Molecule Inhibition of Proteasome and Aggresome Function Induces Synergistic Antitumor Activit...
Small-Molecule Inhibition of Proteasome and Aggresome Function Induces Synergistic Antitumor Activity in Multiple Myeloma
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in multiple myeloma (MM) in both preclinical models and patients with relapsed refractory disease. Recent studies have shown that unfolded and misfolded ubiquitinated proteins are degraded not only by proteasomes, but also by ag...
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Small-Molecule Inhibition of Proteasome and Aggresome Function Induces Synergistic Antitumor Activity in Multiple Myeloma
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TN_cdi_crossref_primary_10_1073_pnas_0503221102
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0503221102
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0503221102
