Retroviral Vector Integration Deregulates Gene Expression but Has No Consequence on the Biology and...
Retroviral Vector Integration Deregulates Gene Expression but Has No Consequence on the Biology and Function of Transplanted T Cells
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The use of retroviral vectors in gene therapy has raised safety concerns for the genotoxic risk associated with their uncontrolled insertion into the human genome. We have analyzed the consequences of retroviral transduction in T cells from leukemic patients treated with allogeneic stem cell transplantation and donor lymphocytes genetically modifie...
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Full title
Retroviral Vector Integration Deregulates Gene Expression but Has No Consequence on the Biology and Function of Transplanted T Cells
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TN_cdi_crossref_primary_10_1073_pnas_0507496103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0507496103
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0507496103
