The Active Metabolite of Clopidogrel Disrupts P2Y12 Receptor Oligomers and Partitions Them out of Li...
The Active Metabolite of Clopidogrel Disrupts P2Y12 Receptor Oligomers and Partitions Them out of Lipid Rafts
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this study, we further deciphered the mechanism of action of clopidogrel and of its active metabolite (Act-Met) on P2Y12 receptors. Using biochemical approaches, we de...
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The Active Metabolite of Clopidogrel Disrupts P2Y12 Receptor Oligomers and Partitions Them out of Lipid Rafts
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TN_cdi_crossref_primary_10_1073_pnas_0510446103
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0510446103
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0510446103
