Therapy-Induced Antibodies to MHC Class I Chain-Related Protein a Antagonize Immune Suppression and...
Therapy-Induced Antibodies to MHC Class I Chain-Related Protein a Antagonize Immune Suppression and Stimulate Antitumor Cytotoxicity
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The activation of NKG2D on innate and adaptive cytotoxic lymphocytes contributes to immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands, such as MHC class I chain-related protein A (MICA), results in immune suppression through down-regulation of NKG2D surface expression. Here we show that some patients who respond t...
Alternative Titles
Full title
Therapy-Induced Antibodies to MHC Class I Chain-Related Protein a Antagonize Immune Suppression and Stimulate Antitumor Cytotoxicity
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0603503103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0603503103
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0603503103
