Apoptosis-Inducing Factor Mediates Poly(ADP-Ribose) (PAR) Polymer-Induced Cell Death
Apoptosis-Inducing Factor Mediates Poly(ADP-Ribose) (PAR) Polymer-Induced Cell Death
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known. Here we identify PAR polymer as a cell death signal that induces release of AIF. PAR polymer induces mit...
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Full title
Apoptosis-Inducing Factor Mediates Poly(ADP-Ribose) (PAR) Polymer-Induced Cell Death
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0606528103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0606528103
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0606528103
