A-803467, a potent and selective Na v 1.8 sodium channel blocker, attenuates neuropathic and inflamm...
A-803467, a potent and selective Na v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
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Author / Creator
Jarvis, Michael F. , Honore, Prisca , Shieh, Char-Chang , Chapman, Mark , Joshi, Shailen , Zhang, Xu-Feng , Kort, Michael , Carroll, William , Marron, Brian , Atkinson, Robert , Thomas, James , Liu, Dong , Krambis, Michael , Liu, Yi , McGaraughty, Steve , Chu, Katharine , Roeloffs, Rosemarie , Zhong, Chengmin , Mikusa, Joseph P. , Hernandez, Gricelda , Gauvin, Donna , Wade, Carrie , Zhu, Chang , Pai, Madhavi , Scanio, Marc , Shi, Lei , Drizin, Irene , Gregg, Robert , Matulenko, Mark , Hakeem, Ahmed , Gross, Michael , Johnson, Matthew , Marsh, Kennan , Wagoner, P. Kay , Sullivan, James P. , Faltynek, Connie R. and Krafte, Douglas S.
Journal title
Language
English
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Scope and Contents
Contents
Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na
v
1.8 have shown that this channel contributes to experimental inflammatory and neuropathic pain. We report here the discovery of A-803467, a sodium channel blocker that potently...
Alternative Titles
Full title
A-803467, a potent and selective Na v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Authors, Artists and Contributors
Author / Creator
Honore, Prisca
Shieh, Char-Chang
Chapman, Mark
Joshi, Shailen
Zhang, Xu-Feng
Kort, Michael
Carroll, William
Marron, Brian
Atkinson, Robert
Thomas, James
Liu, Dong
Krambis, Michael
Liu, Yi
McGaraughty, Steve
Chu, Katharine
Roeloffs, Rosemarie
Zhong, Chengmin
Mikusa, Joseph P.
Hernandez, Gricelda
Gauvin, Donna
Wade, Carrie
Zhu, Chang
Pai, Madhavi
Scanio, Marc
Shi, Lei
Drizin, Irene
Gregg, Robert
Matulenko, Mark
Hakeem, Ahmed
Gross, Michael
Johnson, Matthew
Marsh, Kennan
Wagoner, P. Kay
Sullivan, James P.
Faltynek, Connie R.
Krafte, Douglas S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0611364104
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0611364104
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0611364104
