Full restoration of peripheral Foxp3⁺ regulatory T cell pool by radioresistant host cells in scurfy...
Full restoration of peripheral Foxp3⁺ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Mutations in the gene encoding the transcription factor Foxp3 lead to fatal autoimmune pathology in mice and humans, which is associated with a deficiency in Foxp3⁺ regulatory T cells (Treg). It has also been proposed that Foxp3 inactivation in nonhematopoietic tissues, particularly in thymic epithelium, is required for the pathogenesis, because Fo...
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Full title
Full restoration of peripheral Foxp3⁺ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0702004104
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0702004104
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0702004104
