Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single bio...
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Here, we demonstrate that a single biochemical assay is able to predict the tissue-selective pharmacology of an array of selective estrogen receptor modulators (SERMs). We describe an approach to classify estrogen receptor (ER) modulators based on dynamics of the receptor-ligand complex as probed with hydrogen/deuterium exchange (HDX) mass spectrom...
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Full title
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0710802105
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0710802105
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0710802105
