Bcl-x L induces Drp1-dependent synapse formation in cultured hippocampal neurons
Bcl-x L induces Drp1-dependent synapse formation in cultured hippocampal neurons
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Author / Creator
Li, Hongmei , Chen, Yingbei , Jones, Adrienne F. , Sanger, Richard H. , Collis, Leon P. , Flannery, Richard , McNay, Ewan C. , Yu, Tingxi , Schwarzenbacher, Robert , Bossy, Blaise , Bossy-Wetzel, Ella , Bennett, Michael V. L. , Pypaert, Marc , Hickman, John A. , Smith, Peter J. S. , Hardwick, J. Marie and Jonas, Elizabeth A.
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English
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Contents
Maturation of neuronal synapses is thought to involve mitochondria. Bcl-x
L
protein inhibits mitochondria-mediated apoptosis but may have other functions in healthy adult neurons in which Bcl-x
L
is abundant. Here, we report that overexpression of Bcl-x
L
postsynaptically increases frequency and amplitude of spontaneous miniature...
Alternative Titles
Full title
Bcl-x L induces Drp1-dependent synapse formation in cultured hippocampal neurons
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TN_cdi_crossref_primary_10_1073_pnas_0711647105
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0711647105
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0711647105
